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BioMAT Workstation

Bruker JPK

BioMAT Workstation

Upright optical microscopy and AFM for opaque samples 

The Bruker JPK BioMAT Workstation solves one of the biggest problems in correlative microscopy of non-transparent samples: providing simultaneous access for both techniques. The system enables both upright optical microscopy and AFM to operate at the same location, with no compromise to either.

  • Completely integrated system
  • High resolution imaging and characterisation of the nano-mechanical and nano-electrical sample properties
  • Combine AFM with virtually all upright microscopy techniques, including brightfield, DIC, fluorescence, confocal laser scanning, FLIM FRET, FRAP, FCS, IR and Raman
  • Suitable for operation in liquids
  • Flexible concept with shuttle stage

Contact us for more information and quotes:
+44 (0)1223 422 269 or info@blue-scientific.com

Contact Us Biomat Brochure

Bruker JPK Biomat Workstation

Applications

  • Biochips, cell chips or patterned substrates for cell adhesion
  • Nanostructured surfaces from PDMS and other imprints
  • Lipid bilayers
  • Biomarkers eg quantum dots, rods, CNT
  • Polymers
  • Semiconductors and MEMS/NEMS

Benefits

  • Both AFM and upright optical microscopy on the same surface
  • No compromise to either technique
  • Use in liquids
  • Wide range of applications
  • Characterise nano-mechanical and nano-electrical properties

BioMAT Shuttle Stage

The key component of the BioMAT Workstation is a portable shuttle stage that carries the sample. This transfers the sample between the optics’ field of view and the AFM scan range without losing its position. This transfer can be repeated as many times as you need to, for the sequential measurement of optics and AFM in time lapse studies.

This is even compatible with in-fluid operation, using dipping lenses for the upright microscope.

JPK BioMAT Shuttle Stage

BioMAT shuttle stage with the petri dish heater

Applications

With the JPK BioMAT Workstation you can study samples on non-transparent substrates, such as tissue sections and bacterial growth on metallic surfaces.

In addition to life science applications, the combination of AFM with optics enchances surface chemistry and polymer research, as well as nano-electrical measurements on semiconductors and micro-mechanical systems (MEMS/NEMS).

  • Biochips eg DNA and protein chips
  • Cell-electronics interfaces, cell chips and patterned substrates for cell growth
  • Tissue engineering and implants
  • Bacterial or yeast studies on non-transparent substrates like metals or plastics biofouling
  • Bionics studies
  • Plant biology
  • Nanostructured surfaces from PDMS or other imprints
  • Micromechanical (MEMS/NEMS) systems
  • Nanoparticles, powders, foams, paintings and thin films
  • Organic coatings on metals, plastics or silicone substrates for biocompatible surfaces
  • Nano-electrical measurements of electrical devices

JPK BioMAT example images

1: Gram negative Paracoccus Seriniphilus bacteria. 2: Live CHO cells on gold electrode, measured using the BioMAT PetriDishHeater

Combine with Confocal Laser Scanning Microscopy

By combining high resolution AFM with the latest optical microscopes you can build new experiments for quick and precise sample surveys. These can be combined with nanometre-scale, quick tests of geometry and secondary sample properties including mechanical, electrical and magnetic characteristics.

More details are available in this note.

AFM & Confocal Laser Scanning Microscopy

1: D profile of doped (p, n) semiconductor structure. 2: Corresponding AFM topography. 3: EFM image of the marked region. 4: 3D Overlay of AFM topography and EFM.

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