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Bruker Micro XRF


Fast TXRF Multi-Element Trace Analysis

The Bruker S2 PICOFOX is the world’s first portable benchtop spectrometer for fast quantitative and semi-quantitative multi-element microanalysis of liquids, suspensions, solids and contaminations using TXRF (Total Reflection X-ray Fluorescence Spectroscopy).

TXRF is a highly sensitive technique for trace element analysis, with detection limits in the ppb and ppm range. The S2 PICOFOX is particularly suited to working with very small sample quantities, liquids with high matrix content and research involving different types of samples.

No cooling medium is required, so the analyser can be used not only in the laboratory but also in the field.


  • Simultaneous multi-element trace analysis inc. halogenides
  • Analyse small sample amounts in the nanogram or microgram range
  • Simple quantification using an internal standard
  • Extremely flexible – analyse a wide variety of sample types
  • Use in the lab or on-site in the field
  • No matrix or memory effects
  • Low running costs – no consumables or maintenance
  • Alternative to ICP-MS – easier sample preparation and shorter sampling time

Contact us for more information and quotes:
01223 422 269 or

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Bruker S2 Picofox TXRF

TXRF element rations for coated nanoparticles

Element ratios of coated nanoparticles. The black frame shows the target values.


  • Authentication – in pharmaceuticals and forensics
  • Contamination analysis of wafers, solar cells, OLEDs and nano-particles
  • Quality control of pure substances and industrial products
  • Clinical chemistry – tissues and biological liquids
  • Food – nutrients, dietary supplements and beverages – more info
  • Environmental analysis – contamination of water and soil (video demo)


  • Detect trace elements down to ppb and ppm range
  • Requires only a small quantity of the sample
  • Faster and easier sample preparation than ICP-MS
  • Low running costs – no consumables, gas or liquid nitrogen
  • Simultaneous multi-element analysis

TXRF Applications

The S2 PICOFOX is extremely flexible, so if your application area is not mentioned here, please get in touch!

Nanoparticle analysis


Materials such as nanoparticles are used in the production of industrial and consumer products. Ongoing product development accompanied by increasing concerns about the impact on human health and the environment has lead to a growing demand for versatile analytical technologies. In this example, the S2 PICOFOX was used to analyse element ratios in CdSe nanoparticles coated with ZnS.

Read the lab report…

Pharmaceutical Authenticity Testing

Pharmaceutical Authenticity Testing

Characterisation of brand drugs and their generics is an essential task in pharmaceutical analysis. Alternative methods such as AAS and ICP-OES are restricted by sample quantity, sample digestion and matrix-related difficulties. TXRF can analyse samples in the microgram range. With internal standardisation, no standards for external calibration are required.

Life science TXRF

Life Science

Milk powder quality control

Quality Control of Liquid Nutrients and Milk Powder

Take quantitative measurements of macro- and micro- nutrients. Liquid samples can be analysed directly, and powders need only be suspended in a detergent. Detection limits for micro-nutrients in milk and liquid nutritional products are below 300 ppb.

Other Food Applications

  • Rapid screening for nutrition-relevant elements in fish – read the lab report…
  • Trace element analysis of plant material – read the lab report…
    • Detection of toxic elements
    • Control of essential macro and trace elements for nutrition and fertilisation control of agricultural plants
    • Pesticide and adulterate detection
  • Analysis of lead in tea drinks – read the lab report…
  • Ultra trace analysis of arsenic in rice – more details…
  • Analysis of red and white wines – more details…
Forensics bullet analysis


  • Forensic distance determination after firearm use.
  • Other forensics applications, including characterisation of glass fragments – contact us for details.

Mercury traces in glass

Mercury in Glass

The use of mercury is essential in the lighting industry, although it is a hazardous element. In production and recycling, it is vital to control mercury levels. Due to its high volatility at room temperature, trace analysis of mercury can be complicated. Common methods such as Cold Vapor Atomic Absorption Spectroscopy (CV AAS) are time consuming and cost intensive. TXRF sample preparation is much faster, simpler and does not require acids. The technique also used internal calibration, so no solutions for external calibration need to be prepared.

Water analysis with TXRF


Sample Preparation

Sample preparation is quick, easier and much simpler than for alternative techniques such as ICP-MS. These quick videos show how to prepare suspensions, particles and solid samples:

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